Research Advances in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Authors

Chen Zhu Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China
Zhengming Deng Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China

DOI:

https://doi.org/10.53469/jcmp.2025.07(04).16

Keywords:

Non-alcoholic fatty liver disease (NAFLD), Pathogenesis, Insulin resistance, Lipid metabolism disorder, Gut microbiota

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic disorder characterized by hepatic steatosis. Its prevalence continues to rise against the backdrop of metabolic syndrome and obesity, posing a significant public health threat. Recent advancements in metabolomics, single-cell sequencing, and gene-editing technologies have greatly enhanced our understanding of NAFLD pathogenesis. This article reviews the latest research progress on NAFLD mechanisms, focusing on metabolic dysregulation, inflammatory responses, endoplasmic reticulum (ER) stress, and gut microbiota dysbiosis.

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Published

2025-04-29

How to Cite

Zhu, C., & Deng, Z. (2025). Research Advances in the Pathogenesis of Non-Alcoholic Fatty Liver Disease. Journal of Contemporary Medical Practice, 7(4), 82–85. https://doi.org/10.53469/jcmp.2025.07(04).16