Current Status in Management of Blood Phosphorus During Continuous Renal Replacement Therapy

Abstract

Continuous renal replacement therapy (CRRT) is a significant blood purification technique for acute kidney injury in critically ill patients. Blood phosphorus is an important component of human energy metabolism, cellular signal transduction, and acid-base balance, and maintaining normal blood phosphorus levels is crucial for the maintenance of bodily functions. During CRRT, due to the continuous clearance of phosphates, patients are prone to hypophosphatemia, which can lead to severe consequences such as muscle weakness, respiratory failure, and arrhythmias. Inappropriate phosphorus supplementation may lead to hyperphosphatemia, which is associated with poor prognosis. Therefore, effectively monitoring and managing blood phosphorus levels during CRRT has become an important clinical challenge. This study reviews the effect of CRRT on blood phosphorus metabolism and the mechanism, the dangers of abnormal blood phosphorus during CRRT, the current status of blood phosphorus management during CRRT, and the influencing factors.