Postoperative Adjuvant Therapy for Uterine Epithelioid Angiosarcoma: A Case Report and Review of the Literature

Abstract

Background: Uterine epithelioid angiosarcoma is an extremely rare malignant neoplasm and has a poor prognosis. Therapeutic options that significantly contribute to the survival and prognosis of patients are still being explored. Objective: We hope that by reviewing the literature and sharing our own case can find out the postoperative treatments methods that may be beneficial to the prognosis of patients, especially postoperative adjuvant chemotherapy. Method: We report a new case and reviewed the literature. According to the current diagnostic criteria, we retrieved and identified 15 qualifying cases from PubMed, Scopus, and Web of Science. Moreover, we found a case from China Science and Technology Journal Database (CNKI), which was never reported in the English literature. Results: A 53-year-old female presented with abdominal pain and distension to find to pelvic mass. She was taken for a total abdominal hysterectomy, bilateral salpingo-oophorectomy, sigmoidectomy and sigmoidostomy returned a diagnosis of epithelioid angiosarcoma of the uterus. She was still alive but with suspected metastasis at the time of this report, 6 months after diagnosis. Conclusion: In the future, molecular and immunological deciphering of angiosarcomas may open up avenues for precision medicine to help patients to improve the recognition of the tumor, to avoid potential misdiagnosis and gain better therapeutic strategies for well-established survival benefit.